I've posted two Ted talks, one from 2015 by Doudna about CRISPR and another by Barry Schuler entitled 'Genomics 101' from 2008.  Both are now a bit out of date, but it's interesting to hear both speculate on the future, given what we know now.  To that end is another link to an NPR story about the first person to be treated using CRISPR technology for sickle cell anemia.